dr hab. Magdalena Ślusarz

Wybrane publikacje: 

1. Ślusarz MJ. "Structural basis for antagonist binding to vasopressin V1b receptor revealed by the molecular dynamics simulations", Biopolymers, 2025, 116: e23627, DOI:10.1002/bip.23627
2. Ślusarz R, Sieradzan A, Giełdoń A, Lubecka E, Ślusarz MJ, Leśniewski M, Nguyen TC, Liwo A, Czaplewski C. "UNRES web server: extensions to nucleic acids, prediction of peptide aggregation, and new types of restrained calculations",J Mol Biol, 2025, 437, 1-9:168968. DOI:10.1016/j.jmb.2025.168968 
3. Ślusarz MJ, "How kelch domain-containing protein 3 distinguishes between the C-end degron of herpesviral protein UL49.5 and its mutants" - Insights from molecular dynamics, Bioorg Med Chem, 2024, 109, s.1-8: 117795, DOI:10.1016/j.bmc.2024.117795
4. Ślusarz, M.J., Lipińska, A. "An intrinsic network of polar interactions is responsible for binding of UL49.5 C-degron by the CRL2KLHDC3 ubiquitin ligase" Prot Struct Funct Bioinf, 2023, 2024, vol. 92, nr 5, s.610-622, DOI:10.1002/prot.26651
5. Wąchalska M, Riepe C, Ślusarz MJ, et al. "The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation" Proc Natl Acad Sci U S A. 2024; 121:e2309841121. DOI:10.1073/pnas.2309841121
6. Graul, M., Karska, N., Wąchalska, M., Krupa, P., Ślusarz, M.J., Lubocki, M., Bieńkowska-Szewczyk, K., Rodziewicz-Motowidło, S., Sieradzan, A., Lipińska, A. "The N-terminal proline hinge motif controls the structure of bovine herpesvirus 1-encoded inhibitor of the transporter associated with antigen processing required for its immunomodulatory function" Journal of Molecular Biology,2023,  435, s. 1-24.
7. Ślusarz, M.J. "Molecular insights into the mechanism of sugar-modified enkephalin binding to opioid receptors" Computational Biology and Chemistry, 2022, vol. 101, 1-11.
8. Mazuryk, J., Puchalska, I., Koziński,K., Ślusarz, M.J., Ruczyński, J., Rekowski, P., Rogujski, P.,  Płatek, R., Wiśniewska, M.B., Piotrowski, A., Janus, Ł., Skowron, P., Pikuła, M., Sachadyn, P., Rodziewicz-Motowidło, S., Czupryn, A., Mucha P. "PTD4 peptide increases neural viability in an in vitro model of acute ischemic stroke" International Journal of Molecular Sciences, 2021, vol. 22, nr 11, s.1-23,
9. Karska, N., Graul, M., Sikorska, E., Ślusarz, MJ., Zhukov, I., Kasprzykowski, F., Kubiś, A., Lipińska, A., Rodziewicz-Motowidło, S. "Investigation of the effects of primary structure modifications within the RRE motif on the conformation of synthetic bovine herpesvirus 1‐encoded UL49.5 protein fragments" Chemistry & Biodiversity, 2021, vol. 18, nr 2, s.1-16,
10. Karczyńska, A., Zięba, K., Uciechowska, U., Mozolewska, M., Krupa, P., Lubecka, E., Lipska, A., Sikorska, C., Samsonov, S., Sieradzan, S., Giełdoń, A., Liwo, A., Ślusarz, R., Ślusarz, M., Lee, J., Joo, K., Czaplewski, C. "Improved consensus-fragment selection intemplate-assisted prediction of protein structureswith the UNRES force field in CASP13" Journal of Chemical Information and Modeling, 2020, vol. 60, nr 3, s.1844-1864.
11. Karska, N., Graul, M., Sikorska, E., Zhukov, I., Ślusarz, MJ, Kasprzykowski, F., Lipińska, A., Rodziewicz-Motowidło, S. "Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics" Biochimica et Biophysica Acta-Biomembranes, 2019, vol. 1861, nr 5, s.926-938.
12. Lubecka, E., Karczyńska, A., Lipska, A., Sieradzan, A., Zięba, K., Sikorska, C., Uciechowska, U., Samsonov, S., Krupa, P., Mozolewska, M., Golon, Ł., Giełdoń, A., Czaplewski, C., Ślusarz, R., Ślusarz, M., Crivelli, S.N., Liwo, J.A., "Evaluation of the scale-consistent UNRES force field in template-free prediction of protein structures in the CASP13 experiment" Journal of Molecular Graphics & Modelling, 2019, vol. 92, s.154-166.
13. Zięba, K., Ślusarz, M., Ślusarz, R., Liwo, J.A., Czaplewski, C., Sieradzan, A. "Extension of the UNRES coarse-grained force field to membrane proteins in the lipid bilayer" Journal of Physical Chemistry B, 2019, vol. 123, nr 37, s.7829-7839.
14. Karczyńska, A., Mozolewska, M., Krupa, P., Giełdoń, A., Bojarski, K., Zaborowski, B., Liwo, J.A., Ślusarz, R., Ślusarz, M., Lee, J., Joo, K., Czaplewski, C. "Use of the UNRES force field in template-assisted prediction of protein structures and the refinement of server models: Test with CASP12 targets" Journal of Molecular Graphics & Modelling, 2018, vol. 83, 92-99.
15. Keasar, C., McGuffin, L. J., Wallner, B., Chopra, G., Adhikari, B., Bhattacharya, D., Blake, L., Bortot, L. O., Cao, R., Dhanasekaran, B. K., Dimas, I., Faccioli, R. A., Faraggi, E., Ganzynkowicz, R., Ghosh, S., Ghosh, S., Giełdoń, A., Golon, L., He, Y., Heo, L. , Hou, J., Khan, M., Khatib, F., Khoury, G. A., Kieslich, C., Kim, D. E., Krupa, P., Lee, G. R., Li, H., Li, J., Lipska, A., Liwo, A., Maghrabi, A. H. A., Mirdita, M., Mirzaei, S., Mozolewska, M. A., Onel, M., Ovchinnikov, S., Shah, A., Shah, U., Sidi, T., Sieradzan, A. K., Ślusarz, M., Ślusarz, R., Smadbeck, J., Tamamis, P., Trieber, N., Wirecki, T., Yin, Y., Zhang, Y., Bacardit, J., Baranowski, M., Chapman, N., Cooper, S., Defelicibus, A., Flatten, J., Koepnick, B., Popović, Z., Zaborowski, B., Baker, D., Cheng, J., Czaplewski, C., Delbem, A. C. B., Floudas, C., Kloczkowski, A., Ołdziej, S., Levitt, M., Scheraga, H., Seok, C., Söding, J., Vishveshwara, S., Xu, D. and Crivelli, S. N. "An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12". 2018, Scientific Reports, 8 (1). 9939. ISSN 2045-2322
16. Krupa P, Mozolewska MA, Wiśniewska M, Yin Y, He Y, Sieradzan AK, Ganzynkowicz R, Lipska AG, Karczyńska A, Ślusarz M, Ślusarz R, Giełdoń A, Czaplewski C, Jagieła D, Zaborowski B, Scheraga HA, Liwo A. "Performance of protein-structure predictions with the physics-based UNRES force field in CASP11" Bioinformatics, 2016, 32, 3270-3278.
17. Ślusarz MJ. "Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014)", Expert Opin Ther Pat. 2015, 6, 711-722.
18. Contreras-Romo, M.C., Martínez-Archundia, M., Deeb, O., Ślusarz, M.J., Ramírez-Salinas, G., Garduno-Juárez, R., Quintanar-Stephano, A., Ramírez-Galicia, G., Correa-Basurto, J. "Exploring the ligand recognition properties of the human vasopressin V1a receptor using QSAR and molecular modeling studies", Chem. Biol. Drug. Des., 2014, 83, 207-223.
19. Contreras-Romo, M.C, Correa-Basurto, J., Padilla-Martínez, I., Martínez-Archundia, M., Martínez-Ramos, F., Ślusarz, M.J., López-Pérez, G., Quintanar-Stephano, A. "Theoretical studies, synthesis, and biological activity of 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile (C9) as a non-peptide antagonist of the arginine vasopressin V1a and V2 receptors", Med. Chem. Res., 2014, 23, 1581-1590.
20. Ślusarz, M.J., Sikorska E., Ślusarz, R. "Interactions of vasopressin and oxytocin receptors with vasopressin analogues substituted in position 2 with 3,3'-diphenylalanine - a molecular docking study J. Pept. Sci., 2013, 19, 118-126.
21. Lipinska, N., Zietkiewicz, S., Sobczak, A., Jurczyk, A., Potocki, W., Morawiec, E., Wawrzycka, A., Gumowski, K., Ślusarz, M., Rodziewicz-Motowidlo, S., Chrusciel, E., Liberek, K. "Disruption of Ionic Interactions between the Nucleotide Binding Domain 1 (NBD1) and Middle (M) Domain in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70", J. Biol Chem., 2013, 2857-286.
22. Ślusarz, M.J. "Molecular modeling study of the opioid receptor interactions with series of cyclic deltorphin analogues", J. Pept. Sci., 2011, 17, 554-564.
23. Ślusarz, R., Ślusarz, M.J., Samaszko, J., Madaj, J. "Conformational changes of peptidoglycan fragments during their interactions with vancomycin", Cent. Eur. J. Chem., 2011, 9, 422-431.
24. Danalache, B., Gutkowska, J., Ślusarz, M.J., Berezowska, I., Jankowski, M. "Oxytocin-Gly-Lys-Arg: A Novel Cardiomyogenic Peptide", PLOS One, 2010, 5, e13643.
25. Sikorska, E., Kwiatkowska, A., Sobolewski, D., Ślusarz, R., Ślusarz, M.J. "Influence of bulky 3,3-diphenylalanine enantiomers replacing position 2 of AVP analogues on their conformations: NMR and molecular modeling studies" Eur. J. Med. Chem. , 2010, 45, 4065-4073.
26. Ziętkiewicz, S., Ślusarz, M.J., Ślusarz, R., Liberek, K., Rodziewicz-Motowidło, S. "Conformational stability of the full-atom hexameric model of the ClpB chaperone from Escherichia coli" Biopolymers, 2010, 93, 47-60.
27. Ślusarz, R., Ślusarz, M.J. "An Influence of the Aromatic Side Chains Conformations in Positions 2 and 3 of Vasopressin Analogs on Interaction with Vasopressin and Oxytocin Receptors" QSAR Comb. Sci., 2009, i28, 1166-1175.
28. Ślusarz, M.J., Ślusarz, R., Ciarkowski, J. "Molecular dynamics study of the internal water molecules in vasopressin and oxytocin receptors" Protein Pept. Lett., 2009, 16, 342-350.
29. Ślusarz, R., Sikorska, E., Ślusarz, M.J. "Theoretical study on interactions of bicyclic vasopressin analogues with human neurohypophyseal hormone receptors" QSAR Comb. Sci., 2008, 27, 834-840.
30. Witt, M., Ślusarz, M.J., Ciarkowski, J. "Molecular Modeling of Vasopressin V2 Receptor Tetramer in Hydrated Lipid Membrane" QSAR Comb. Sci., 2008, 27, 684-693.
31. Ślusarz, M.J., Ślusarz, R., Ciarkowski, J. "Vasopressin and oxytocin receptors interactions with agonists and antagonists - molecular modeling study" Peptides 2006, eds. K.Rolka, P.Rekowski, J.Silberring, Kenes International, 2007, 366-367.
32. Ślusarz, R., Ślusarz, M.J., Lammek, B. "Molecular modeling-based study of new vasopressin analogs affinity toward human neurohypophyseal hormone receptors",Peptides 2006, eds. K.Rolka, P.Rekowski, J.Silberring, Kenes International, 2007, 396-397.
33. Ślusarz, M.J., Sikorska, E., Ślusarz, R., Ciarkowski, J. "Molecular docking-based study of vasopressin analogues modified at positions 2 and 3 with N-methylphenylalanine: influence on receptor-bound conformations and interactions with vasopressin and oxytocin receptors" J. Med. Chem., 2006, 49, 2463-2469.
34. Sikorska, E. Ślusarz, M.J., Lammek, B. "Conformational studies of AVP analogues modified with N-methylphenylalanine enantiomers in dimethyl sulfoxide solution" Biopolymers, 2006, 82, 603-614.
35. Ślusarz, M.J., Ślusarz, R., Ciarkowski, J. "Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors - molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system" Biopolymers, 2006, 81, 321-338.
36. Ślusarz, M.J., Ślusarz, R., Ciarkowski, J. "Molecular dynamics simulation of human neurohypophyseal hormone receptors complexed with oxytocin - modeling of an activated state." J. Pept. Sci., 2006, 12, 171-179.
37. Ślusarz, M.J., Giełdoń, A., Ślusarz, R., Ciarkowski, J. "Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors - molecular dynamics study of the activated receptor-vasopressin-Gα systems." J. Pept. Sci., 2006, 12, 180-189.
38. Ślusarz, R., Ślusarz, M.J., Lammek, B., Ciarkowski, J. "Molecular Modeling of MetaII rhodopsin." QSAR Comb. Sci., 2006, 25, 105-113.
39. Sikorska, E., Ślusarz, M.J., Ślusarz R., Lammek B. "Investigation of cis/trans ratios of peptide bonds in AVP analogues containing N-methylphenylalanine enantiomers", J. Pept. Sci., 2006, 12, 13-24.
40. Ślusarz, M.J., Giełdoń A., Ślusarz, R., Meadows, R., Trojnar, R., Ciarkowski, J. "Study of new oxytocin antagonist barusiban (Fe200 440) affinity toward human oxytocin receptor versus vasopressin V1a and V2 receptors - molecular dynamics simulation in POPC bilayer." QSAR Comb. Sci., 2005, 24, 603-610.
41. Ślusarz, M.J., Ślusarz, R., Meadows, R., Trojnar, R. and Ciarkowski, J. "Molecular dynamics of complexes of atosiban with neurohypophyseal receptors in the fully hydrated phospolipid bilayer." QSAR Comb. Sci., 2004, 23,536-545.
42. Ślusarz, M.J., Ślusarz, R., Kaźmierkiewicz, R., Trojnar, J.,Wiśniewski K., Ciarkowski, J. "Molecular modeling of the neurohypophyseal receptor/atosiban complexes." Protein Pept. Lett., 2003, 3, 295-302.